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Get inspired
Our current prototype systems are principally engineered for research related to particle characterization. They integrate critical functions while enabling the configuration of many upstream and downstream accessories.
Researchers focused on testing, instrumentation and public health may also be interested in the current generation of ES-DMA systems.
Read on to learn how ES-DMA applies to your focus area.
VIRAL VECTORS
AAV Capsid Analytics
AAV vectors are critically important to gene therapy drug efficacy, yet they remain a challenge to characterize. Our NanoRanger has been shown to distinguish AAV capsids based on size differences measured in Angstroms, featuring low cost and ease of use and correlating closely with DNA content verified by orthogonal testing with gold standards.
Structural Virology
With resolutions (FWHM) up to 100x, size ranges from 20-120 nm, and gentle treatments, NanoRanger offers unprecedented ability to characterize VLPs in their native state. Are capsids complete? Are protein envelopes in place? Are anti-bodies attached? These questions can now be answered.
Capsid Engineering
Capsid engineering lies at the heart of many approaches to increasing CQAs and lowering production cost of gene therapy drugs. NanoRanger offers fast insights into capsid diameters in minutes, speeding R&D cycles and bringing breakthroughs closer to reality.
BIOLOGICS
Antibodies
Monoclonal antibodies have become the juggernauts of biologic drugs in terms of industry revenues and public health benefits. Many production and stability problems remain, and inexpensive tools to characterize samples at-line and at strategic points in the supply chain are major QC opportunities. High resolution ES-DMA has been shown to, for example, distinguish antibody particles based on oxidization, with many more potential applications.
Vaccines
With resolutions (FWHM) up to 100x, size ranges from 5-250 nm, and gentle treatments, NanoRanger offers unprecedented ability to characterize VLPs and provide quality control for viral vector based vaccines. New research may show similar benefits for LNPs and polymeric nanoparticles leading development of new vaccines.
Protein oligomers
The activity of protein oligomers and small aggregates have been explored as both cause and cures of critical genetic diseases such as Alzheimers and Parkinsons. Our unique capability to measure mass invariant size conformations, and to collect after separation, amount to powerful tools for drug discovery in these areas.
POINT OF CARE TESTING
Viral diagnostics
The big one. The reason we get up in the morning. Help us determine if ES-DMA is right for your chosen viral pathogen.
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NO MORE PANDEMICS!
Threat protection
Not point-of-care, but point of presence. Military bases, government facilities, nursing homes, cruise ships and resorts, convention centers, corporate HQs, even the home. ES-DMA holds the promise of creating virus-free zones through screening.
Veterinary and Zoonotics
The ES-DMA method should be equally effective on humans, pets and livestock. With less red tape, we may see NanoEngineering systems in vets' offices before doctors' offices.
ENVIRONMENTAL RESEARCH
Climate change
Many nano-particles in the atmosphere play a role in explaining climate change. Compared to mass spec, our systems offer faster, less expensive and more portable characterization and quantification of such particles.
Emissions
Recent studies have shown that nano-particles (1-100nm) may represent health hazards, sparking strong interest in their surveillance and characterization. Vehicles, power generation, manufacturing, and government regulatory policy are potential beneficiaries of the superior resolution of DMA.
Waste water monitoring
Waste water samples may be important predictors of pathogen outbreaks. Sample volumes are large and PCR may be cost and time prohibitive. ES-DMA needs to be explored for viability as a low-cost, continuous flow testing method.
INDUSTRIAL APPLICATIONS
Nanoresins
Plastics manufacturers enhance their products with nano-sized resins as additives to impart special thermal, conductive and optical characteristics to end products. Our systems can enhance process control and QC testing.
Viral Vector Manufacturing
The high resolution, low cost and continuous sampling features enable our systems to play a key role in measuring yield and testing for uniformity and contamination.
Standards
With resolutions similar to electron microscopy at a fraction of the cost and cycle time, ES-DMA can play a key role in the development of nano-particle standards.